One major issue debated in the by-election was the Government’s plans to build the new HS2 rail link through the areas’ Chiltern Hills.
Other analysts point to deeper sentiments, because of the fact that Liberal Democrat Sarah Green secured a majority of 8,028, which overturned a seat held by the Tories since 1974.
Polling guru Professor John Curtice reacted to the Chesham and Amersham win by pointing out that most citizens in the constituency voted to stay in the EU.
Speaking to BBC Radio 4’s Today programme he said: “The result was a combination of the Remain inclination of the constituency and a number of local issues, HS2, planning.”
He added: “Labour voters, who of course the majority are Remain voters, were quite happy to switch to the Liberal Democrats.”
Lord Adonis was derided with suggestions that he was over-reacting after the Chesham and Amersham Liberal Democrat win.
One Twitter follower of Lord Adonis responded with a sarcastic tweet and said: “Yes, The Lib Dems rocketing from 11 to 12 seats is going to make all the difference.
However, one Twitter follower of Lord Adonis supported him and said: “Absolutely right Andrew.
“The tide has definitely started to turn.
“Reality was always going to kick in eventually.”
After the win Liberal Democrat leader Sir Ed Davey said the win for his party in Buckinghamshire sent a “shockwave through British politics”.
The Liberal Democrat leader said it was a “record-breaking” victory and part of a trend of beating the Tories in the south.
He said that this was the beginning of a pattern and pointed to recent local election gains for the Liberal Democrats in Oxfordshire, Cambridgeshire, Hertfordshire, Surrey and Wiltshire.
Mr Davey, speaking to the BBC’s Today programme, said: “People feel that the Conservatives are out of touch, they’re not listening to places like this, they’re taking them for granted.”
The Conservative Party explained their loss was because “by-elections are always difficult for the governing party” to win.
Conservative chairwoman Amanda Milling said the “work starts now to show how it’s the Conservatives that can deliver on the people’s priorities and regain their support”.