NBC Universal’s Mike Sington wrote on Twitter: “Prince Harry gets his name in lights, as he makes a rock star appearance to a standing ovation in Los Angeles.”
The Hollywood Reporter’s Chris Gardner added: “Well, he’s here!
“Los Angeles LOVES Prince Harry tonight – he gets electric reception and standing ovation as he steps out on the biggest stage since moving down the road in Montecito.”
The event to promote coronavirus vaccines was Harry’s first public appearance since Prince Philip’s funeral on April 17.
It was also his first engagement in the US since he and Meghan gave their dramatic interview to Oprah Winfrey in March.
The concert raised donations to Covax, which is working to provide vaccines for low and middle-income countries.
It was hosted by US singer Selena Gomez and will be broadcast in full next Saturday.
The event also featured musical performances by Jennifer Lopez, Pearl Jam’s Eddie Vedder and the Foo Fighters.
US President Joe Biden, First Lady Jill Biden and Vice President Kamala Harris are also committed to make special appearances.
In his speech, Prince Harry praised the heroic work and sacrifice of frontline healthcare workers around the world.
He said: “Tonight is a celebration of each of you here, the vaccinated frontline workers in the audience and the millions of frontline heroes around the world.
In a statement prior to the concert, the Duke and Duchess of Sussex said: “Over the past year, our world has experienced pain, loss, and struggle – together. Now we need to recover and heal – together.
“We can’t leave anybody behind. We will all benefit, we will all be safer, when everyone, everywhere has equal access to the vaccine.
“We must pursue equitable vaccine distribution, and, in that, restore faith in our common humanity. This mission couldn’t be more critical or important.”