She added that people drawing such comparisons was a case of “women tearing down other women”.
On Thursday, Mrs Biden sent shockwaves through the Internet when photographs obtained at Andrews Air Force Base in Maryland showed her wearing black floral-patterned fishnet stockings.
The fashion statement was widely commented on across social media platforms, with some users labelling the garments “trashy”.
One person said: “Madonna called and wants her trashy look back, Doc.”
Another commenter added: “Looks ridiculous…
“That’s an outfit for a 3 year old not for an elderly.”
Other Twitter users defended Mrs Biden, with one person hailing the look as “fabulous,” while others took aim at the former First Family.
One user brought one of Donald Trump’s controversial moments into the debate, saying: “Honestly, if you’re more offended by FLOTUS wearing fishnets than the (former) President mocking disabled people then you are the problem.”